Dr. Prem S. Kaushal
Laboratory of Structural Biology
M. Sc. University of Jammu, Jammu.
Ph. D. Indian Institute of Science, Bangalore
Dr. Prem Kaushal obtained his Ph. D. in macromolecular crystallography and biophysics from Indian Institute of Science, Bangalore under the tutelage of Professor M. Vijayan. Then he joined Professor Chris Dealwis lab. at the Case Western Reserve University (CWRU), Cleveland, OH, USA and worked on ribonucleotide reductases these convert the ribose sugar to deoxyribose sugar. At the CWRU, Dr. Kaushal got interested in cryo- electron microscopy (cryo- EM) and moved to the Dr. Rajendra Agrawal lab. at Wadsworth Center, Albany, NY. USA.
At the Wadsworth Center he has applied the cutting-edge techniques of the single-particle reconstruction cryo-EM to illustrate the architecture of ribonucleoprotein complexes, such as bacterial group II introns and ribosomes. Bacterial group II introns are large catalytic RNAs related to nuclear spliceosomal introns and eukaryotic retrotransposons. The first 3.8 Å resolution cryo-EM structure of Lactococcus lactis group IIA intron, in complex with an intron-encoded protein, LtrA, revealed the functional coordination of the intron RNA with the LtrA protein.
His lab is now applying a multidisciplinary approach of structural biology to understand the molecular mechanism of protein synthesis in Plasmodium falciparum and in mycobacteria to exploit the unique features of parasite translational machinery to improve the efficacy of known drug molecules and find new drug targets for therapeutics.