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Dr. Murali Bashyam
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Molecular Oncology Group
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Home » Molecular Oncology » Research
Molecular Oncology
Research Interests

The principal research interest of the lab is to comprehensively understand the biology of specific cancer types that are common in India and/or are distinct from their western counterpart(s). To this end, we use genomic, molecular genetic, molecular pathology and cell biology tools to identify and characterize recurrent genetic alterations in tumor samples.

Positions-We are currently seeking potential PhD students and post docs to work on computational analysis of next generation sequencing data generated in house as well as elsewhere for various cancer types. The strategy may involve a combination of cell and molecular biology approaches in cell lines and tumor xenografts in addition to computational analyses. Specific projects include identification and validation of gene fusions, allele specific expression and alternative / novel transcript isoforms through comparative analysis of whole genome / exome / RNA Seq datasets. Additional opportunities are also available to work on unraveling the importance of the SWI/SNF chromatin remodeling complex in cancer. Students and post docs will be given freedom to develop the project(s) as per their own interests.

Details of current projects are given below:
  1. Studying novel nuclear and cytoplasmic functions of ARID1B.
    https://doi.org/10.1242/jcs.251637

  2. Molecular Characterization of early-onset rectal cancer.
    doi: 10.1038/s41388-020-01537-z

  3. Characterisation of gain of function activity of non-hotspot p53 mutations identified from Indian squamous cell carcinoma patients.
    https://doi.org/doi:10.1002/jcp.29332

  4. Molecular analysis of genetic disorders.
Contact Information
Email: bashyam<at>cdfd.org.in
bashyam69<at>gmail.com
Phone: +91-40-27216112
Fax: +91-40- 27216006
Last updated on : Monday, 22nd March, 2021.

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